This training video introduces USC’s Single IRB (sIRB) process and explains when and how it applies to federally funded, multi-site research. It outlines USC’s key limitation of serving as the sIRB only for studies with four or fewer non-USC sites, highlights when external IRBs must be used, and emphasizes the importance of early planning and budgeting. By the end, Principal Investigators will understand their responsibilities, the steps in the USC process, and how to avoid delays in grant submissions.

Single IRB at USC: What Every PI Needs to Know

Introduction 

What is a Single IRB?

When USC IRB Will Serve

When USC IRB Will Not Serve

Why This Matters for PIs

Requesting USC as sIRB

The USC sIRB Process

Responsibilities of the Principal Investigator 

Key Takeaways

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