This review explores the MFa signal sequence, a pivotal tool in yeast protein secretion. It details historical development, mechanisms, and key challenges like missorting and aggregation. We highlight innovative strategies, including optimized MFa variants and strain engineering, to enhance recombinant protein yield and quality for biotechnological and therapeutic applications.

MFa Signal: Unlocking Yeast's Protein Secretion Frontier

Introduction to MFa Signal Sequence

Challenges in Protein Secretion

Innovations and Strategies

Future Prospects of MFa Signal Sequence

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